小胶质细胞/巨噬细胞特异性蛋白抗体–Iba1抗体,兔(免疫组化)

小胶质细胞/巨噬细胞特异性蛋白抗体–Iba1抗体,兔(免疫组化)
Anti Iba1, Rabbit (for Immunocytochemistry)

  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

小胶质细胞/巨噬细胞特异性蛋白抗体–Iba1抗体,兔(免疫组化)小胶质细胞/巨噬细胞特异性蛋白抗体--Iba1抗体,兔(免疫组化)

Anti Iba1, Rabbit (for   Immunocytochemistry)


小胶质细胞标记抗体(免疫染色用)

产品编号

产品名称【中文名称】

规格

包装

019-19741

Anti Iba1, Rabbit (for   Immunocytochemistry)

【抗Iba1,兔(免疫细胞化学)】

免疫化学用

50 μg

抗体信息

抗原名

Iba1

适用

实验

免疫

染色

同种型

IgG

免疫染色图像

小胶质细胞/巨噬细胞特异性蛋白抗体--Iba1抗体,兔(免疫组化)

抗原信息

Iba1C末端序列肽

物种交叉反应性

人,小鼠,大鼠

标签

非标签

抗原别名

AIF-1, IRT1, Protein G1

免疫

动物

克隆号


(多克隆抗体)

详细信息

Iba1是与巨噬细胞/小胶质细胞特异性表达,分子量17000的钙结合蛋白。近年来,小胶质细胞除了对神经营养·保护作用以外,产生的NO、TNF- α、IL-1 β对神经伤害作用很受关注。

本产品是与小胶质细胞特异性反应的兔多克隆抗体,适用于与星形胶质细胞特异性GFAP单克隆抗体的双重染色。

使用文献

[1] Jun,et al.(2017).Nature,551(7679),232-236.

[2] Gibson,et al.(2014).Science,344(6183),1252304.

[3] Yan,et al. (2018).Cell, S009286741830285X.

[4] Pil,et al. (2018). Nature Medicine.

欲了解相关资料请点击文字:

Wako神经生物学抗体清单

巨噬细胞/小胶质细胞Iba1抗体

◆相关资料


Iba1抗体选择指南


小胶质细胞/巨噬细胞特异性蛋白抗体--Iba1抗体,兔(免疫组化)

小胶质细胞/巨噬细胞特异性蛋白抗体--Iba1抗体,兔(免疫组化)Iba1抗体选择指南.pdf

参考文献


◆Nature


 1.

Lam, C.K., et al.: Nature, 465, 478(2010).

Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.

 2.

Stefater, J. A. 3rd. et al.: Nature, 474, 511(2011).   

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells

 3.

Deng, H. X., et al.: Nature, 477, 211(2011).

Mutations in UBQLN2 cause dominant X-linked juvenile and adult onset ALS and ALS/dementia.

 4.

Lee, Y., et al.: Nature, 487, 433(2012).

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

 5.

Heneka, M. T., et al.: Nature, 493, 674(2013).

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.

 6.

Shao, W., et al.: Nature, 494, 90(2013).

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

 7.

Zhang, G., et al.: Nature, 497, 211(2013).

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

 8.

Chung, W. S., et al.: Nature, 504, 394(2013).

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways.

 9.

Roth, T. L., et al.: Nature, 505, 223(2014).

Transcranial amelioration of inflammation and cell death after brain injury

10.

Najm, F. J., et al.: Nature, 522, 216(2015).

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.


11.

Fourgeaud, L., et al.: Nature, 532, 240(2016).

TAM receptors regulate multiple features of microglial physiology.

12.

Vasek, M. J., et al.: Nature, 534, 538(2016).

A complement-microglial axis drives synapse loss during virus-induced memory impairment.


13.

Iaccarino, H. F., et al.: Nature, 540, 230(2016).

Gamma frequency entrainment attenuates amyloid load and modifies microglia.

14.

Bialas, A. R. et al.: Nature, 546, 539(2017).

Microglia-dependent synapse loss in type I interferon-mediated lupus

15.

Mass, E., et al.: Nature, 549, 389(2017).

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.

16.

Jun, J. J., et al.: Nature, 551, 232(2017).

Fully integrated silicon probes for high-density recording of neural activity.

17.

Bussian, T. J., et al.: Nature, 562, 578(2018).
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.

◆CELL


 1.

Lujambio, A., et al.: Cell, 153, 2, 449(2013).

Non-Cell-Autonomous Tumor Suppression by p53.

 2.

Parkhurst, C. N., et al.: Cell, 155, 7, 1596(2013).

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic

factor.

 3.

Wang, Y., et al.: Cell, 160, 6, 1061(2015).

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model.

 4.

Keren-Shaul, H., et al.: Cell, 169, 7, 1276(2017).

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.

 5.

Ulland, T. K., et al.: Cell, 170, 4, 649(2017).

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease.

 6.

Qin, Y., et al.: Cell, 174, 1, 156(2018).

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.

 7.

Yan, S., et al.: Cell, 173, 4, 989(2018).

A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in

Huntington's Disease

◆Nature Medicine


 1.

Heppner, F. L., et al.: Nat. Med., 2, 146(2005).  

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

 2.

Nikić, I., et al.: Nat. Med., 4, 495(2011).

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple

sclerosis.


 3.

Vom, B. J., et al.: Nat. Med., 12, 1812(2012).

Inhibition of IL-12/IL-23 signaling reduces Alzheimer’s disease–like pathology and cognitive

decline

 4.

Minami, S. S., et al.: Nat. Med., 10, 1157(2014).

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse

models.

 5.

Yun, S. P., et al.: Nat. Med., 7, 931(2018).

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.

 6.

Mount, C. W., et al.: Nat Med. 5, 572(2018).

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas.

 

◆Nature Neuroscience


 1.

Zhang, K., et al.: Nat. Neurosci., 10, 1064(2003).

HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes

neurodegeneration.

 2.

Ajami, B., et al.: Nat. Neurosci., 12, 1538(2007).

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

 3.

Mildner, A., et al.: Nat. Neurosci., 12, 1544(2007).

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host

conditions.

 4.

Bero, A. W., et al.: Nat. Neurosci., 6, 750(2011).

Neuronal activity regulates the regional vulnerability to amyloid-β deposition.

 5.

Fancy, S. P., et al.: Nat. Neurosci., 14, 1009(2011).

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.

 6.

Ajami, B., et al.: Nat. Neurosci., 14, 1142(2011).

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.

 7.

Mosher, K. I. et al.: Nat. Neurosci., 11, 1485(2012).

Neural progenitor cells regulate microglia functions and activity.

 8.

Lehmann, S. M., et al.: Nat. Neurosci., 6, 827(2012).

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes

neurodegeneration.


 9.

Kierdorf, K., et al.: Nat. Neurosci., 3, 273(2013).

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

10.

Bialas, A. R. et al.: Nat. Neurosci., 12, 1773(2013).

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

11.

Butovsky, O., et al.: Nat. Neurosci., 1, 131(2014).

Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia.

12.

Saito, T., et al.: Nat. Neurosci., 5, 661(2014).

Single App knock-in mouse models of Alzheimer's disease.

13.

Erny, D., et al.: Nat. Neurosci., 7, 965(2015).

Host microbiota constantly control maturation and function of microglia in the CNS.


14.

Sorge, R. E. et al.: Nat. Neurosci., 8, 1081(2015).

Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

15.

Hama, H., et al.: Nat. Neurosci., 10, 1518(2015).

ScaleS: an optical clearing palette for biological imaging.

16.

Asai, H., et al.: Nat. Neurosci., 11, 1584(2015).

Depletion of microglia and inhibition of exosome synthesis halt tau propagation.

17.

Guan, Z., et al.: Nat. Neurosci., 1, 94(2016).

Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.

18.

Grabert, K., et al.: Nat. Neurosci., 3, 504(2016).

Microglial brain region-dependent diversity and selective regional sensitivities to aging

19.

Gonçalves, J. T., et al.: Nat. Neurosci., 6, 788(2016).

In vivo imaging of dendritic pruning in dentate granule cells

20.

Liu, Q., et al.: Nat. Neurosci., 2, 243(2016).

Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.

21.

Safaiyan, S., et al.: Nat. Neurosci., 8, 995(2016).

Age-related myelin degradation burdens the clearance function of microglia during aging.

22.

Pandya, H., et al.: Nat. Neurosci., 5, 753(2017).

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

23.

Füger, P., et al.: Nat. Neurosci., 10, 1371(2017).

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

 

◆Nature Immunology


 1.

Wang, Y., et al.: Nat. Immunol., 13, 753(2012).

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and

microglia.

 2.

Goldmann, T., et al.: Nat. Immunol., 17, 797(2016).

Origin, fate and dynamics of macrophages at central nervous system interfaces


 3.

Haimon, Z., et al.: Nat. Immunol., 19, 636(2018).

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies.

◆Nature Biotechnology


 1.

Park, S. I., et al.: Nat. Biotechnol., 33, 1280(2015).

Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

 2.

Staahl, B. T., et al.: Nat. Biotechnol., 35, 431(2017).

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein

complexes

◆Nature Methods


 1.

Clark, J. J., et al.: Nat. Methods., 7, 126(2010).

Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

 2.

Prevedel, R., et al.: Nat. Methods., 13, 1021(2016).
Fast volumetric calcium imaging across multiple cortical layers using sculpted light

◆Neuron


 1.

Simard, A. R., et al.: Neuron, 49, 4, 489(2006).

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in

Alzheimer's disease.

 2.

Bhaskar, K., et al.: Neuron, 68, 1, 19(2010).

Regulation of tau pathology by the microglial fractalkine receptor.

 3.

Bergmann, O., et al.: Neuron, 74, 4, 634(2012).

The Age of Olfactory Bulb Neurons in Humans

 4.

Schafer, D. P., et al.: Neuron, 74, 4, 691(2012).

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.

 5.

Paolicelli, R. C., et al.: Neuron, 95, 2, 297(2017).

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.

 6.

Tufail, Y., et al.: Neuron, 93, 3, 574(2017).

Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia.

 7.

Abud, E. M., et al.: Neuron, 94, 2, 278(2017).

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.

 8.

Bohlen, C. J., et al.: Neuron, 94, 4, 759(2017).

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by

Defined-Medium Cultures.

 9.

De, Biase, L. M., et al.: Neuron, 95, 2, 341(2017).

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

10.

Hwang, H. W., et al.: Neuron, 95, 6, 1334(2017).

cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity

and Shifts Araf Isoforms with Microglia Activation.

11.

Lehrman, E. K., et al.: Neuron, 100, 1, 120(2018).

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.

12.

López-Erauskin, J., et al.: Neuron, 100, 4, 816(2018).

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease

Without Nuclear Loss-of-Function of FUS

产品编号 产品名称 产品规格 产品等级 产品价格
019-19741 Anti Iba1, Rabbit (for   Immunocytochemistry) 
抗Iba1,兔(免疫细胞化学)
50μg 免疫化学用