前列腺素E2酶联免疫试剂盒

前列腺素E2酶联免疫试剂盒
PGE2 ELISA kit

  • 产品特性
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  • 参考文献

前列腺素E2酶联免疫试剂盒前列腺素E2酶联免疫试剂盒

PGE2 ELISA kit

 

  用于炎症和类花生酸研究的高灵敏度前列腺素E2酶联免疫试剂盒。

 

  研究背景:前列腺素E2(PGE2)由于其在炎症、癌症、动脉粥样硬化、自身免疫性疾病和脓毒症中具有重要地位而被广泛研究。氧化的花生四烯酸通过前列腺素合成酶(COX-1和COX-2)生成前列腺素H2(PGH2),被前列腺素合成酶进一步代谢成主要产物前列腺素E2(PGE2)。前列腺素E2(PGE2)通过与细胞表面的G-蛋白偶联受体(EP1、EP2、EP3和EP4)的结合来介导自分泌和旁分泌的信号传导,从而调节磷脂酶C和腺苷酸环化酶活性。PGE2作为一种治疗靶点,无论是通过COX抑制剂(NSAIDS)调节其合成,还是通过下调其与受体结合或结合拮抗剂,都引起了人们极大的兴趣。在各种组织中产生的前列腺素E2(PGE2)已在多种生理过程中表现出了调节作用,包括在肾脏中尿钠排泄,血管中平滑肌的弹性,以及单核细胞和巨噬细胞对损伤组织的炎症作用。

 


◆产品特点


● 高灵敏度测定,可检测最少13.4 pg/ml的前列腺素E2

● 3小时内即可获得多大37个样本重复检测的高通量格式的结果

● 广泛引用于同行评审文献中

● 准备使用的液体颜色编码试剂以便减少错误发生

● 每次使用和不同批次产品获得良好重复性的结果

 

前列腺素E2酶联免疫试剂盒 前列腺素E2酶联免疫试剂盒

 

    

[1]

Colon cancer-derived myofibroblasts increase   endothelial cell migration by glucocorticoid-sensitive secretion of a   pro-migratory factor: Z. Drebert, et al.; Vascul. Pharmacol. 89, 19 (2017), Application(s): Determine the concentrations of   prostanoids in conditioned medium from myofibroblasts and HUVECs, and in   HUVEC lysates, Abstract;

[2]

Expression of toll-like receptor-1 by bradykinin in   human gingival fibroblasts: J.A. Arreguin-Cano T; Int. J. Clin. Exp. Pathol. 10, 1283 (2017), Application(s): Measurement of PGE2 in   supernatant., Full Text

[3]

Human and feline   adipose-derived mesenchymal stem cells have comparable phenotype,   immunomodulatory functions, and transcriptome: H.C. Clark, et al.; Stem Cell   Res. Ther. 8, 69 (2017), Application(s): Measurement of PGE2   in supernatant of human and feline cells., Abstract; Full Text

[4]

Novel augmentation   by bufalin of protein kinase C-induced cyclooxygenase-2 and IL-8 production   in human breast cancer cells: H.T. Chen, et al.; Innate Immun. 23, 54 (2017), Abstract; Full   Text

[5]

Prostaglandin E2 stimulates the expression of cumulus   expansion-related genes in pigs: the role of protein kinase B: M. Blaha, et   al.; Prostaglandins Other Lipid Mediat. 130, 38 (2017),   Application(s): ELISA using pig samples, Abstract;

[6]

A positive feedback loop between progesterone and   microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of   both in mouse granulosa cells: K. Tamura, et al.; Prostaglandins Other Lipid   Mediat. 123, 56 (2016), Application(s): Measurement of   PGE2 in the culture media, Abstract;

[7]

Anti-inflammatory effects of 6′-O-acetyl mangiferin   from Iris rossii Baker via NF-κb signal blocking in   lipopolysaccharide-stimulated RAW 264.7 cells: J.H. Jang, et al.; Chem. Biol.   Interact. 2797, 30303 (2016), Application(s):   Determination of PGE2 production, Abstract;

[8]

Dimethyl fumarate activates the prostaglandin EP2   receptor and stimulates cAMP signaling in human peripheral blood mononuclear   cells: S.E. Fiedler, et al.; Biochem. Biophys. Res. Commun. 475, 19 (2016), Application(s): Supernatant PGE2 was measured,   Abstract;

[9]

Directly interact with Keap1 and LPS is involved in the   anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced   macrophages and endotoxemia: Y.S. Chiou, et al.; Free. Radic. Biol. Med. 94, 1 (2016), Application(s): Measurement of prostaglandin E2   (PGE2) level in culture medium, Abstract;

[10]

Effects of Almond-   and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary   Supplementation on Inflammation Associated to Exercise and Age: X. Capo, et   al.; Nutrients 8, 619 (2016), Application(s): Cytokine,   Eicosanoids and Adhesion Molecules Determination, plasma, Abstract; Full   Text

[11]

Enhanced   anti-inflammatory activity of brown seaweed Laminaria japonica by   fermentation using Bacillus subtilis: H.T.V. Lin, et al.; Process Biochem.   (2016), Application(s):   Measurement of prostaglandin E2 (PAGE2), cell supernatant,

[12]

Grid-like surface structures in thermoplastic   polyurethane induce anti-inflammatory and anti-fibrotic processes in bone   marrow-derived mesenchymal stem cells: Y. Roger, et al.; Colloids Surf. B   Biointerfaces 148, 104 (2016), Application(s): ELISA   using human bone marrow-derived mesenchymal stem cell supernatant, Abstract;

[13]

Implantation and   pregnancy outcome of Sprague-Dawley rats fed with low and high salt diet:   G.O. Oludare, et al.; Middle East Fertil. Soc. J. (2016), Application(s): Measured rat serum PGE2 levels,

[14]

In vitro bioactive   properties of phlorotannins recovered from hydrothermal treatment of   Sargassum muticum: M.P. Casas, et al.; Sep. Purif. Technol. 167, 117 (2016), Application(s): Determination of the   amount of PGE2 in thawed plasma supernatants,

[15]

Isolation and   Identification of a Flavone Apigenin from Marine Red Alga Acanthophora   spicifera with Antinociceptive and Anti-Inflammatory Activities: G.A. El   Shoubaky, et al.; J. Exp. Neurosci. 10, 21 (2016), Application(s): TNF-α measured in mouse blood samples, Abstract; Full   Text

[16]

Local   intra-uterine Ang-(1-7) infusion attenuates PGE2 and 6-keto PGF1α in   decidualized uterus of pseudopregnant rats: K.B. Brosnihan, et al.; Reprod.   Biol. Endocrinol. 14, 68   (2016), Application(s):   Assaying tissue extracts, Abstract; Full Text

[17]

MRI-Based   Assessment of Intralesional Delivery of Bone Marrow-Derived Mesenchymal Stem   Cells in a Model of Equine Tendonitis: A. Scharf, et al.; Stem Cells Int. 2016, 1 (2016), Application(s): Assessing the   ability of MSCs to modulate the inflammatory response, Abstract; Full   Text

[18]

Resokaempferol-mediated anti-inflammatory effects on   activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38   MAPK signaling pathways: Q. Yu, et al.; Int. Immunopharmacol. 38, 104 (2016), Application(s): PGE2 was measured in mouse   supernatant, Abstract;

[19]

The Prostaglandin   E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4   Inflammasome Activation: X. Wang, et al.; PLoS One 12, e1005803 (2016), Application(s): PGE2 measurement in cell lysates, Abstract; Full Text

[20]

Antagonizing   Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the   Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells: K. Jung, et   al.; PLoS One 10, e0124417   (2015), Application(s):   ELISA using human culture supernatant , Abstract; Full Text

[21]

Anti-inflammatory effect of desoxo-narchinol-A isolated   from Nardostachys jatamansi against lipopolysaccharide: J.Y. Shin, et al.;   Int. Immunopharmacol. 29, 730 (2015), Application(s):   PGE2 level was measured by ELISA in mice, Abstract;

[22]

Effectiveness of   the combinational treatment of Laminaria japonica and Cistanche tubulosa   extracts in hair growth: K. Shin, et al.; Lab. Anim. Res. 31, 24 (2015), Application(s): ELISA using mouse exudate, Abstract; Full Text

[23]

Insight into the molecular mechanism of an herbal   injection by integrating network pharmacology and in vitro: Y.M. Ma, et al.;   J. Ethnopharmacol. 173, 91 (2015), Application(s): ELISA   using mouse RAW264.7 cells , Abstract;

[24]

Lipin-1 contributes to modified low-density   lipoprotein-elicited macrophage pro-inflammatory responses: A.R. Navratil, et   al. ; Atherosclerosis 242, 424 (2015), Application(s):   ELISA using mouse cell culture supernatant, Abstract;

[25]

Molecular characterization and knock-down of salmon   louse (Lepeophtheirus salmonis) prostaglandin E synthase: C. Eichner, et al.;   Exp. Parasitol. 159, 79 (2015), Application(s): ELISA Kit   measuring PGE2 levels in salmon lice, Abstract;

[26]

Prostaglandin E2   Production and T Cell Function in Mouse Adenovirus Type 1 Infection following   Allogeneic Bone Marrow Transplantation: M.K. McCarthy, et al.; PLoS One 10, e0139235 (2015), Application(s): PGE2 concentration   in bronchoalveolar lavage fluid , Abstract; Full Text

[27]

Role of gastric   acid inhibition, prostaglandins and endogenous-free thiol groups on the   gastroprotective effect of a proteolytic fraction from Vasconcellea   cundinamarcensis latex: A. Silva, et al.; J. Pharm. Pharmacol. 67, 133 (2015), Application(s): EIA using rat tissue   samples, Abstract; Full Text

[28]

Supplement of   5-hydroxytryptophan before induction suppresses inflammation and   collagen-induced arthritis: T.H. Yang, et al. ; Arthritis. Res. Ther. 17, 364 (2015), Application(s): Measurement of PGE2   in mice serum samples, Abstract; Full Text

[29]

The cancer pain related factors affected by celecoxib   together with cetuximab in head and neck squamous cell carcinoma: Y. Yang, et   al.; Biomed. Pharmacother. 70, 181 (2015),   Application(s): ELISA using human culture medium, Abstract;

[30]

The Receptor   CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced   Pro-Inflammatory Mediators during Microglial Activation: A. Ejarque-Ortiz, et   al.; PLoS One 10, e0123928   (2015), Application(s):   ELISA using mouse microglial supernatant, Abstract; Full Text

[31]

Inhibition of   COX-2 and PGE2 in LPS-stimulated RAW264.7 cells by lonimacranthoide VI, a   chlorogenic acid ester saponin: F. Guan, et al.; Biomed. Rep. 2, 760 (2014), Application(s): Assay of   LPS-stimulated RAW264.7 macrophages, Abstract; Full Text

[32]

Possible roles of   COX-1 in learning and memory impairment induced by traumatic brain injury in   mice: J. Shang, et al.; Braz. J. Med. Biol. Res. 47, 1050 (2014), Application(s): Analysis of PGE2 levels in mouse hippocampus tissue, Abstract; Full   Text

[33]

Prostaglandin E2   promotes features of replicative senescence in chronically activated human   CD8+ T cells: J.P. Chou, et al.; PLoS One 9, e99432 (2014), Application(s): EIA using cell culture supernatants, Abstract; Full Text

[34]

Anti-inflammatory, antioxidative and matrix   metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured   macrophages and keratinocytes: W.Y. Choi, et al.; J. Pharm. Pharmacol. 65, 310 (2013), Application(s): EIA using culture supernatants,   Abstract;

[35]

Colorectal carcinoma-derived fibroblasts modulate   natural killer cell phenotype and antitumor cytotoxicity: T. Li, et al.; Med.   Oncol. 30, 663 (2013), Application(s): EIA using culture   supernatants, Abstract;

[36]

Melanoma-educated CD14+ cells acquire a myeloid-derived   suppressor cell phenotype through COX-2-dependent mechanisms: Y. Mao, et al.;   Cancer Res. 73, 3877 (2013), Application(s): EIA using   culture supernatants, Abstract;

[37]

Microenvironment   generated during EGFR targeted killing of pancreatic tumor cells by ATC   inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent   pathway: A. Thakur, et al.; J. Transl. Med. 11, 35 (2013), Application(s): EIA using culture supernatants from 3D co-cultures, Abstract; Full   Text

[38]

Prostaglandin E2 alteration in contraceptive consumers:   as a risk factor for inflammatory diseases: M.S. Pour, et al.; Arch. Gynecol.   Obstet. 287, 1031 (2013), Application(s): EIA using human   serum, Abstract;

[39]

Transmigration of   Neural Stem Cells across the Blood Brain Barrier Induced by Glioma Cells: M.   Díaz-Coránguez, et al.; PLoS One 8, e60655 (2013), Application(s): Quantification was done in 4 day CM derived from rat   astrocytes and glioma C6 cells using ELISA, Abstract; Full Text

[40]

XH-14, a novel   danshen methoxybenzo[b]furan derivative, exhibits anti-inflammatory   properties in lipopolysaccharide-treated RAW 264.7 cells: G.M. Park, et al.;   J. Inflamm. 10, 1 (2013), Application(s): EIA using culture   supernatants, Abstract;   Full Text

[41]

Acacetin protects   dopaminergic cells against 1-methyl-4-phenyl-1, 2, 3,   6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo: H.G.   Kim, et al.; Biol. Pharm. Bull. 35, 1287 (2012), Application(s): EIA using culture supernatants, Abstract; Full Text

[42]

Hepatocellular carcinoma-associated fibroblasts trigger   NK cell dysfunction via PGE2 and IDO: T. Li, et al.; Cancer Lett. 318, 154 (2012), Application(s): EIA using culture   supernatants, Abstract;

[43]

Lycorine inhibits lipopolysaccharide-induced iNOS and   COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs   activation and increases the survival rate of mice after LPS challenge: J.   Kang, et al.; Int. Immunopharmacol. 12, 249 (2012),   Application(s): EIA using culture supernatants, Abstract;

[44]

Matrix metalloproteinase-19 is a key regulator of lung   fibrosis in mice and humans: G. Yu, et al.; Am. J. Respir. Crit. Care Med. 186, 752 (2012), Application(s): PGE2 from mice BAL was   measured, Abstract;

[45]

Delta6-desaturase (FADS2) deficiency unveils the role   of omega3- and omega6-polyunsaturated fatty acids: W. Stoffel, et al.; EMBO   J. 27, 2281 (2008), Application(s): EIA using tissue,   Abstract;

[46]

Anti-inflammatory effects of isoflavone powder produced   from soybean cake: T.H. Kao, et al.; J. Agric. Food Chem. 55,   11068 (2007), Application(s): EIA using peritoneal exudate fluid and   peritoneal exudate cell supernatant, Abstract;

[47]

Celecoxib inhibits Cdx2 expression and prevents gastric   cancer in Helicobacter pylori-infected Mongolian gerbils: S. Futagami, et   al.; Digestion 74, 187 (2006), Abstract;

[48]

Spinal   inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2   subtype: H. Reinold, et al.; J. Clin. Invest. 115, 673 (2005), Application(s): PGE2 from the thoracolumbar segment of the spinal cord was   measured, mice, Abstract;   Full Text

[49]

Effect of a selective cyclooxygenase-2 inhibitor,   nimesulide, on the growth of lung tumors and their expression of   cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma: M.S.   Shaik, et al.; Clin. Cancer Res. 10, 1521 (2004),   Application(s): EIA using mouse tissue, Abstract;

[50]

Nonopioid actions of intrathecal dynorphin evoke spinal   excitatory amino acid and prostaglandin E2 release mediated by   cyclooxygenase-1 and -2: L. Koetzner, et al.; J. Neurosci. 24,   1451 (2004), Application(s): EIA using dialysate, Abstract;

[51]

Differential expression of platelet-activating factor   acetylhydrolase in macrophages and monocyte-derived dendritic cells: S.   Al-Darmaki, et al.; J. Immunol. 170, 167 (2003),   Application(s): EIA using human culture supernatants, Abstract;

[52]

Inhibition of cyclooxygenase-2 by rofecoxib attenuates   the growth and metastatic potential of colorectal carcinoma in mice: M. Yao,   et al.; Cancer Res. 63, 586 (2003), Application(s):   Concentration of PGE2 in splenic tumor cystosolic fractions were determined   using mouse tissue, Abstract;

[53]

Microsomal   prostaglandin E synthase-1 is a major terminal synthase that is selectively   up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in   the rat adjuvant-induced arthritis model: D. Claveau, et al.; J. Immunol. 170, 4738 (2003), Application(s): PGE2 production was   determined by enzyme immunoassay analysis using rat tissue, Abstract; Full   Text

[54]

Increased levels of the pro-inflammatory prostaglandin   PGE2 in CSF from ALS patients: G. Almer, et al.; Neurology 58,   1277 (2002), Application(s): EIA using cerebral spinal fluid, Abstract;

[55]

The effects of periodontal therapy on intracrevicular   prostaglandin E2 concentrations and clinical parameters in pregnancy: F.   Yalcin, et al.; J. Periodontol. 73, 173 (2002),   Application(s): EIA using gingival crevicular fluid, Abstract;

[56]

Promoter   methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2   expression in gastric epithelial cells: M. Akhtar, et al.; Cancer Res. 61, 2399 (2001), Application(s): EIA   using cell culture supernatant, Abstract; Full Text

[57]

Inflammatory agonists induce cyclooxygenase type 2   expression by human neutrophils: C.G. Maloney, et al.; J. Immunol. 160, 1402 (1998), Application(s): EIA using human cell culture   supernatant, Abstract;

[58]

Selective cyclooxygenase-2 inhibition by nimesulide in   man: L. Cullen, et al.; J. Pharmacol. Exp. Ther. 287, 578   (1998), Application(s): EIA using plasma, Abstract;

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