免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

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免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

◆活性免疫检测点蛋白

B7-H4 (human):Fc (human) (rec.)

CHI-HF-210B7H4

B7-H4 (mouse):Fc (mouse) (rec.)

CHI-MF-110B7H4

CTLA-4 (human):Fc (human) (rec.)

CHI-HF-210A4

CTLA-4 (human):Fc (human) (rec.) (non-lytic)

CHI-HF-220A4

CTLA-4 (human):Fc (mouse) (rec.)

CHI-HF-211A4

CTLA-4 (mouse):Fc (mouse) (rec.)

CHI-MF-110A4

CTLA-4 (mouse):Fc (mouse) (rec.) (non-lytic)

CHI-MF-120A4

PD-1 (human):Fc (human) (rec.)

CHI-HF-210PD1

PD-1 (human):Fc (human) (rec.) (non-lytic)

CHI-HF-220PD1

PD-1 (mouse):Fc (mouse) (rec.)

CHI-MF-110PD1

PD-L1/B7-H1 (human):Fc (human) (rec.)

CHI-HF-210PDL1

PD-L1/B7-H1 (human):Fc (human) (rec.) (non-lytic)

CHI-HF-220PDL1

PD-L1/B7-H1 (mouse):Fc (mouse) (rec.)

CHI-MF-110PDL1

PD-L1/B7-H1 (mouse):Fc (mouse) (rec.) (non-lytic)

CHI-MF-120PDL1

PD-L2 (human):Fc (human) (rec.)

CHI-HF-210PDL2

PD-L2 (human):Fc (human) (rec.) (non-lytic)

CHI-HF-220PDL2

PD-L2 (mouse):Fc (mouse) (rec.)

CHI-MF-110PDL2

 IDO1酶&主要抑制剂

IDO1   (human) Enzyme+Inhibitor Set

AG-44B-0006

IDO1 (human) (rec.) (His) (highly active)

AG-40B-0161

 

  MMG-0358                  Potent Triazole IDO1 Inhibitor                          AG-CR1-3630

                                                                                 

免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

IC50值,mIDO1细胞检测是2nM,hIDO1细胞检测是80nM,hIDO1(pH 6.5)酶活检测是330nM,hIDO1(pH7.4)的酶活检测是71nM。体内有活性。


参考文献


Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012)

肿瘤免疫治疗的LAG-3

功能性封闭抗体

LAG-3 (human), mAb (blocking) (17B4)

AG-20B-0012

LAG-3 (human), mAb (blocking) (17B4) (preservative   free)

AG-20B-0012PF

LAG-3, mAb (blocking) (11E3)

AG-20B-0011

LAG-3, mAb (blocking) (11E3) (preservative free)

AG-20B-0011PF

生物活性蛋白

LAG-3 (human):Fc (human) (rec.)

AG-40B-0031

LAG-3 (mouse):Fc (mouse) (rec.)

AG-40B-0039

T-细胞免疫球蛋白和粘蛋白结构域

Tim-3 (human):Fc (human) (rec.)

CHI-HF-210T3

Tim-3 (mouse):Fc (mouse) (rec.)

CHI-MF-110T3

CD1d配体抗肿瘤佐剂

α-Galactosylceramide

Potent NKT Cell stimulator

强有效NKT 激活剂

AG-CN2-0013

 

免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3


在人类和小鼠NKT细胞里MHC-I蛋白和CD1d分子脂质结合的特异性配体。




参考文献


LIT: Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine: F. Gableh, et al.; J. 

Biomed. Sci. 23, 16 (2016)

免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

CD1d配体

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